Arsenal and Manchester City take a break from their battle at the top of the Premier League to try and remain on course for a quadruple this weekend as Wigan and Salford seek monumental FA Cup shocks.
Aston Villa and Newcastle are also aiming to end their seven-decade waits for FA Cup glory when they face off in the tie of the round.
Arsenal host Wigan, winners of the FA Cup in 2013, who currently sit in the League One relegation zone on Sunday, while fourth-tier Salford, co-owned by United legends David Beckham and Gary Neville, head to the Etihad hoping to avoid a repeat of the 8-0 thrashing they suffered at the hands of City last season.
Villa are the best of the rest behind the Premier League’s top two, but with winning the title now a distant dream, Unai Emery’s men are aiming to end a 30-year wait to win a major trophy.
Villa’s last FA Cup success was back in 1957, two years after Newcastle last lifted the trophy.
Newcastle ended their 70-year drought for domestic silverware by winning the Carabao Cup last season.
Sitting 10th in the Premier League, the Magpies may need FA Cup glory to salvage an otherwise disappointing campaign.
However, Newcastle have struggled on the road all season and are likely to be without influential captain Bruno Guimaraes due to a hamstring injury.
See the full fixtures below:
Friday
Hull v Chelsea
Wrexham v Ipswich
Saturday
Burton v West Ham
Burnley v Mansfield
Norwich v West Brom
Manchester City v Salford
Southampton v Leicester
Port Vale v Bristol City
Aston Villa v Newcastle
Liverpool v Brighton
Sunday
Birmingham v Leeds
Grimsby v Wolves
Stoke v Fulham
Oxford v Sunderland
Arsenal v Wigan
Monday
Macclesfield v Brentford
Arsenal
